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DN1172V1 03-5472 Depakote ER. July 12, 2006 Page 1 of 39. DEPAKOTE® ER. (divalproex sodium) extended-release tablets. BOX WARNING. HEPATOTOXICITY. . free valproate was decreased by 50% in 7 patients with cirrhosis and by 16% in 4 patients with acute hepatitis, compared. . For example, when switching. The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets.. VA and VAS are available in different dosage forms; capsule, tablet, enteric-coated tablet, sprinkle, liquid, intravenous, suppository and controlled-release formulations[8].

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